Showing posts with label pharma. Show all posts
Showing posts with label pharma. Show all posts

Friday, June 27, 2014

Blogging and Biotech: A fun and creative piece emphasizing the Value Creation potential of Social Technologies in Biotech


Imagine a young, enthusiastic scientist (I will call him Edward) sitting—Macbook in lap—on a second hand couch in a flat just outside the walls of the his University (which I will call Top Rank University). Just yesterday, and after little more than one year as a post-doctoral fellow with the Department of Pathology, Edward received his Certification of Completion of Postdoctoral Research for his innovative work on target discovery for antibody therapeutics. Now, he sits with his Macbook and evaluates several interesting pharmaceutical companies, one of which will become his first employer outside academia.

A few months ago, after entering “antibody therapeutics” into a Google search at 11pm one night, Edward found a blog discussing the production of fully human therapeutic antibodies from transgenic mice. Immediately, he noted that the blog was extremely informative, simple, elegant, the #1 return from his Google search, and maintained by an obviously social technology savvy pharmaceutical company (which I will call SocialTech Pharma). “Cool! This is exactly the company I want to work for,” thought Edward just before falling asleep.

Skip forward three years, and Edward is working at SocialTech Pharma. Just three years earlier, Edward was one of 300 scientists, representing over 40 countries and nearly every globally prestigious academic institution, who applied for the Immunobiology Scientist position at SocialTech Pharma. In just three years, he helped the company pioneer the field of Rapid Fire Drug Discovery (RFDD) by spearheading a project to create a novel automated drug discovery system called OmniPATH.

Step back two years. On his one-year anniversary at SocialTech Pharma, Edward received a call from Craig Venter, who had been following SocialTech’s blog, press releases, and progress in RFDD. This conversation between Edward and Venter initiated a sequence of events resulting in the creation of OmniPATH. Shortly after their first meeting at a coffee shop near by, they contacted numerous Biotech companies and academic institutions looking for potential collaborators. It was extraordinarily easy for Edward to find other scientists willing to partner with SocialTech Pharma, since everyone was very familiar with and trusting of SocialTech due to the company’s global presence and transparency within the global scientific community, a key result of maintaining an extremely resourceful and public company blog.

Ultimately, Edward and Venter, together with six other scientists from SocialTech collaborated with scientists from four partnering biotech companies and six academic institutions to create an automated drug discovery system, OmniIPATH. OmniPATH combines target discovery, synthetic biology, reverse immunology, and bioinformatics in order to 1) rapidly mass produce therapeutic antibodies and vaccines to practically any disease or pathogen, and 2) re-engineer any therapeutic antibody or vaccine—at a moment’s notice—in response to drug immunogenicity or evasive adaptations of a pathogen. OmniPATH rapidly carried SocialTech into global spotlight as the leader of health care innovation, and of course a champion of strategic social collaboration.

Obviously, this fantastic story is completely fictional. Yet it enacts the extraordinary benefits, or Value Creation, that can spawn from proper use of social technologies. In July 2012, McKinsey & Company, a global management consulting firm, released an extensive report investigating the current and potential impact of social technologies on the economy, with emphasis on Pharmaceutical, High Tech, Telecom, Legal, Retail, and Financial enterprises (see The social economy: Unlocking value and productivity through socialtechnologies). McKinsey’s report analyzed social technology usage across multiple enterprises representing “almost 20 percent of global industry sales” and estimated that “between $900 billion and $1.3 trillion in value can be unlocked through the use of social technology” within the examined business sectors; keeping in mind that these figures are based on ideal conditions. Moreover, McKinsey reported “two-thirds of the value creation opportunity afforded by social technologies lies in improving communications and collaboration within and across enterprises.”

Social technologies, something as simple as a company blog, if properly used and maintained, can dramatically improve communication and collaboration both within the company and between external parties, regardless of geographies and time zones, and “at virtually zero marginal cost,” according to McKinsey. A successful company blog creates a unified and powerful voice, and can serve as a cyber-conduit through which information is immediately communicated and easily accessed at a later time if needed.

The biggest and most powerful impact of a company blog is EXPOSURE. By increasing its global presence, establishing greater connections with patients and potential collaborators, and instilling trust within local and global scientific communities, a pharmaceutical company can exponentially increase its Value Creation potential over time. And with numerous methods of regulating blog usage, visibility and content, the company can feel confident knowing its property and its image are well protected.

In the fictional story presented above, Edward chose to apply for the Immunobiology Scientist position at SocialTech because in following the company’s blog—which lead him to the company website, which lead him to the job posting, which prompted him to apply—he acquired a high level of respect for and interest in the company. Since the company blog drew considerable attention to SocialTech Pharma, Edward found that many pharmaceuticals, biotechs, and academic institutions were excited to collaborate or form partnerships. Due to the well-informed and personable voice of SocialTech’s blog, most scientists Edward contacted felt as though they already knew and trusted the company, similar to how one might feel about a friend. Ultimately, by strategically socially collaborating and partnering with various organizations, SocialTech was able to develop OmniPATH, a revolutionary healthcare technology.


Of course, if anyone anywhere wishes to know more about OmniPATH, they can simply read about it on SocialTech’s blog.

Thursday, June 5, 2014

Transparency of Drug Pricing Data: Part 1

Below is a LinkedIn discussion which unfortunately came to end after I posted additional topics of interest for further debate.  I hope to continue this discussion by FIRST giving additional readers the opportunity to review the all previous comments and SECONDLY posting an updated version of the additional topics I presented on LinkedIn (see Transparency of Drug Pricing Data: Part 2).


And this is where the story ends...for now.

If you are still interested, See Transparency of Drug Pricing Data: Part 2

Transparency of Drug Pricing Data: Part 2


The price of  health care  treatment is a hot topic, both in America and Internationally. Seemingly innumerable news and web articles, Tweets, blogs, health care conferences, etc. are discussing the issue of rising medical costs, with well structured arguments both FOR and AGAINST these price increases. I’ve heard laudable comments and viewpoints of many reputable and intellectual voices, but most seem to limit themselves to clearly and thoroughly explaining the status quo. Commonly, when I observe someone propose a new idea or theoretical solution to one or several facets of the cost of health care dilemma, I can’t help noticing the plethora of critical opposition ready to pounce without first properly exploring said idea or solution.

Recently, TRANSPARENCY is a word one sees quite frequently, especially affiliated with health care costs and drug pricing.  As many patients find the cost of their health care increasingly financially burdensome, they are demanding more information in order to a) better understand the high prices and b) determine if a more affordable option is available.  Some information health care consumers are requesting include, but are not limited to diagnostic costs (what hospitals charge for a CT scan) and pricing data (such as Pharma R&D, company merger and marketing costs, among others, that influence pricing of a drug or medical device).

I’m particularly interested in exploring the idea of improving transparency, which is why I am posting this discussion. I’m asking any interested readers to explore this topic and comment however you wish.  Maybe you are FOR transparency. Maybe you are AGAINST transparency. Or maybe you would simple like to provide a circular argument on which others can ruminate.  Whatever your opinions are, please share them so that others may benefit from your knowledge.

Below are some factors (a few with supplemental questions) I view as having influence (direct or indirect) on drug pricing and the cost of health care (not necessarily all inclusive).  Any comments pertaining to the topic of health care costs, drug pricing and TRANSPARENCY are welcome.

1.  R&D costs relevant to the pricing of a new drug or medical device.

2. The cost of company mergers relevant to the pricing of a new drug or medical device (especially since this is a prevalent topic in current news).

3. The cost of competing drugs or medical devices.

4. The cost for insurance companies to cover aberrantly high-priced drugs or medical devices for certain treatments.

5. Duration of a drug’s patent protection upon entry into the market.

6. The impact that the First-Inventor-to-File (FITF) law has on potentially giving more leverage to companies that are more equipped to quickly reach filing stage.

7. The impact of an inevitable future generic drug on the pricing of a current brand drug (keep in mind the common complaint that generic birth control medications do not always act the same as their brand counterpart).

8. For aberrantly high-priced drugs or medical devices (such as Gilead's Hepatitis C drug, Sovaldi), what financial aid options could patients find until a cheaper generic drug enters the market? Will a given insurance company be expected to help in this regard (this is where my knowledge is most limited)? And if so, how might this high expense on insurance companies affect the overall health care system?

9. Regarding competition keeping prices in check, what happens if the rate of innovation falls and companies start consolidating to balance a lack in new, in-house quality-of-health sustaining drugs that would reap big financial rewards (especially since shareholders are always demanding greater returns)? And might competition be further stifled due to the FITF law?

Although I previously posted this discussion on LinkedIn (see Transparency of Drug Pricing Data: Part 1), no one has yet attempted to directly address the complex and multi-faceted topic outlined above.  If you would like some background information before commenting, below you will find several links to relevant articles.

Rise and Fall of the American Medical Empire - by Robert A. Linden
Bad Pharma - by Ben Goldacre
America's Broken Health Care System: The Role of Drug, Device Manufacturers
Why does Gilead's Sovaldi cost $84K in the U.S. and $57K in Britain?
Why do Hospitals Charge $4,423 for $250 CT Scans? Blame Arizona Republicans
First Million-Dollar Drug Near After Prices Double on Dozens of Treatments
Can You Afford Your Medicine? Doctors Don’t Ask
Hatch-Waxman Act 1984 (Drug Price Competition & Patent Term Restoration)
First Inventor to File (uspto.gov)
Ultimately, I hope this post will initiate a collaborative discussion and benefit all those who follow.  Please feel free to openly comment.

Sincerely,


Cole